GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound can help lower blood sugar and support weight loss. If you are taking one of these medications, your food choices can make a big difference in how well they work and how you feel in the process, but there’s not one particular diet that should be followed. However, there are a few dietary basics that can improve your experience.
Since the medications work by slowing digestion and suppressing appetite, a focus on eating nutrient-rich foods that your body can easily digest and experimenting with GLP-1 recipes that keep you satisfied will help you see positive results while minimizing gastrointestinal side effects. Although each person has to find what works best for them, here are 6 diet basics to follow when taking GLP-1 medications:
- Eat enough food. Some people find it difficult to consume enough calories to stay energized, which can leave them feeling tired, sluggish and unwell. If you can’t eat enough solid food, consider drinking high-protein smoothies or shakes to get enough calories, protein and nutrients. Also, don’t go too long without eating. Aim to eat a little bit every few hours.
- Don’t eat too much at once. It’s not uncommon to feel too full or uncomfortable after eating a big meal, or even after eating a meal that used to leave you feeling satisfied. Slower digestion means you will likely feel full after eating less than you’re used to. Eating several smaller meals and snacks throughout the day is usually preferable to eating a few bigger meals.
- Prioritize protein. One of the most important nutrients you need when taking GLP-1s is protein. Not only does it help you stay full but it helps preserve lean muscle mass. Rapid weight loss increases the chance that you’ll lose muscle in addition to fat, but eating protein helps. Strength training is also essential to preserve lean muscle as much as possible.
- Don’t skimp on fiber. Many people on GLP-1s experience constipation, but eating enough fiber-rich foods can help everything move through your system more smoothly. Fiber can be found in fruits, vegetables, whole grains and legumes like lentils or black beans. Fiber supplements may also be needed. Increase fiber intake slowly and drink enough water to improve fiber’s effect.
- Stay hydrated. GLP-1 medications can make you dehydrated and it’s easy to forget to drink enough when you don’t have much of an appetite. Proper hydration helps keep your digestive system moving and may lessen other side effects. It also supports weight loss and is essential for all bodily functions. Get in the habit of keeping a water bottle nearby to sip throughout the day.
- Avoid “junk” foods. Although you can technically eat anything you want when taking GLP-1s, many people find that foods high in fat or sugar cause unwanted side effects such as nausea, vomiting, bloating and diarrhea. Fried foods, sweets and highly processed foods don’t need to be completely sworn off, but it’s best to enjoy them only sparingly and in small portions.
Everyone reacts differently to GLP-1 medications, which is why the best eating plan is one that makes you feel good while seeing positive results. If you are having a hard time figuring out what to eat, are struggling with side effects or are not seeing the reduction in blood sugar or weight you are expecting, talk to a doctor or registered dietitian for advice or dietary recommendations.
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Date Last Reviewed: June 17, 2025
Editorial Review: Andrea Cohen, Editorial Director, Baldwin Publishing, Inc. Contact Editor
Medical Review: Jane Schwartz, RDN, CLT
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